Dr. Jianjie Wang

Details

Education

• PhD, 2005, University of Missouri-Columbia  
• MD, 1991, Tianjin Medical University           

Teaching

• BMS 308 Human Physiology (lecture and lab)
• BMS 498 Undergraduate Research
• BMS 565 Human Cardiopulmonary Physiology
• BMS 569 Neurobiology
• BMS 585 Histology
• BMS 730 Current Literature Topic
• BMS 752 Medical Physiology
• BMS 798 Research

Professional experience

Recent publications

• Jianjie Wang, Murtaza M. Kazmi, Virginia H. Huxley. Microvascular Sex- and Age- Dependent Phosphodiesterase Expression (Corresponding author). Frontiers in Aging-Molecular Mechanisms of Aging. 27 July 2021. doi: 10.3389.
• Jianjie Wang, Joseph Harvey, Richard Garrad, Virginia Huxley, Laurie Erb, Gary Weisman. Simple, Reliable Isolation, Purification and Cultivation of Murine Skeletal Muscle Microvascular Endothelial Cells. (Corresponding author) J Biomed Sci Eng. 2020, 13(12) December 2020.
• Virginia H. Huxley, Scott Kemp, Christine Schramm, Steve Sieveking, Susan Bingaman, Yang Yu, Isabella Zaniletti, Kevin Stockard, and Jianjie Wang. Sex differences influencing micro- and macrovascular endothelial phenotype in vitro. J Physiology (2018) Sep; 596(17):3929-3949. doi: 10.1113/JP276048. Epub 2018 Jul 15.
• Amanda Hoffman, Xiaotong Wu, Jianjie Wang, Amanda Brodeur, Rintu Thomas, Ravindra Thakkar, Halena Hadi, Garry P. Glaspell, Molly Duszynski, Adam Wanekaya and Robert K. DeLong. Two-Dimensional Fluorescence Difference Spectroscopy of ZnO and Mg Composites in the Detection of Physiological Protein and RNA Interactions, Materials 2017, 10(12), 1430; doi:10.3390/ma10121430.
• Z. Liao, C. Cao, J. Wang, V. H. Huxley, O. Baker, G. A. Weisman, L. Erb. The P2Y2 Receptor Interacts with VE-Cadherin and VEGF Receptor-2 to Regulate Rac1 Activity in Endothelial Cells. J Biomed Sci Eng. 2014 Dec 7(14), 1105-1121. 

Research and professional interests

• Vascular inflammation, including vascular and endothelial permeability, and leukocyte-endothelial interaction
• Insulin resistance

Inflammation is associated with various diseases, including cardiovascular disease, diabetes, and cancer. Vascular leak or hyperpermeability and increased leukocyte-endothelial interaction are hallmarks of inflammation.

Dr. Wang's laboratory uses animal and cell models to analyze endothelial signaling molecules and biological sex that regulate microvascular permeability and leukocyte-endothelial interaction under resting and stimulating conditions. Multiple research approaches have been employed in her research including intravital microscopy, cell culture, RT-PCR, immunoblot, flow cytometry, and immunostaining.

Awards and honors